A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to σ1 and σ2 receptors. Many compounds exhibited nanomolar affinity for σ1 subtype receptor with good selectivity over σ2. A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed
Design, synthesis, and SAR analysis of novel selective sigma(1) ligands
ORTUSO F;ALCARO S
2007-01-01
Abstract
A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to σ1 and σ2 receptors. Many compounds exhibited nanomolar affinity for σ1 subtype receptor with good selectivity over σ2. A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussedFile in questo prodotto:
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