IRIS
COSTA, GIOSUE'
 Distribuzione geografica
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Continente #
NA - Nord America 2.338
AS - Asia 1.653
EU - Europa 985
SA - Sud America 296
AF - Africa 37
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 3
Totale 5.317
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Nazione #
US - Stati Uniti d'America 2.259
SG - Singapore 755
IT - Italia 474
CN - Cina 398
BR - Brasile 226
IN - India 178
VN - Vietnam 172
DE - Germania 131
GB - Regno Unito 116
SE - Svezia 66
CA - Canada 53
FI - Finlandia 52
UA - Ucraina 48
HK - Hong Kong 34
AR - Argentina 33
JP - Giappone 22
ID - Indonesia 18
MX - Messico 16
ZA - Sudafrica 15
ES - Italia 14
EE - Estonia 12
IQ - Iraq 12
BD - Bangladesh 10
NL - Olanda 10
RU - Federazione Russa 10
CO - Colombia 9
FR - Francia 8
CZ - Repubblica Ceca 7
EC - Ecuador 7
PL - Polonia 7
DZ - Algeria 6
UZ - Uzbekistan 6
CL - Cile 5
IR - Iran 5
LT - Lituania 5
PK - Pakistan 5
TN - Tunisia 5
TR - Turchia 5
EG - Egitto 4
PE - Perù 4
RO - Romania 4
SA - Arabia Saudita 4
UY - Uruguay 4
EU - Europa 3
JO - Giordania 3
KR - Corea 3
MA - Marocco 3
PY - Paraguay 3
TW - Taiwan 3
VE - Venezuela 3
AE - Emirati Arabi Uniti 2
AL - Albania 2
AT - Austria 2
BO - Bolivia 2
CH - Svizzera 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
IE - Irlanda 2
IL - Israele 2
KE - Kenya 2
KG - Kirghizistan 2
MY - Malesia 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
PT - Portogallo 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
AM - Armenia 1
AU - Australia 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BY - Bielorussia 1
CR - Costa Rica 1
CU - Cuba 1
CW - ???statistics.table.value.countryCode.CW??? 1
CY - Cipro 1
GP - Guadalupe 1
GR - Grecia 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
HU - Ungheria 1
KW - Kuwait 1
KZ - Kazakistan 1
LC - Santa Lucia 1
LV - Lettonia 1
MD - Moldavia 1
NG - Nigeria 1
NP - Nepal 1
PH - Filippine 1
PR - Porto Rico 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
SY - Repubblica araba siriana 1
TT - Trinidad e Tobago 1
Totale 5.317
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Città #
Dallas 432
Chandler 295
Singapore 251
Ashburn 162
Santa Clara 137
Hefei 132
Bengaluru 131
Milan 108
Lawrence 99
Princeton 99
Munich 98
London 84
Chicago 70
Ho Chi Minh City 68
Beijing 61
Wilmington 61
Catanzaro 42
Los Angeles 37
Hanoi 35
Ottawa 35
Turku 35
Hong Kong 31
Des Moines 30
São Paulo 27
Tokyo 19
Brooklyn 18
New York 17
San Nicola Manfredi 16
Helsinki 15
Rome 15
Shanghai 15
Palermo 14
San Francisco 14
Seattle 13
Boardman 12
Haiphong 12
Washington 12
Hanover 11
Pune 11
Chennai 10
Johannesburg 10
Guangzhou 9
Redmond 9
Aversa 8
Charlotte 8
Norwalk 8
Biên Hòa 7
Boston 7
Curitiba 7
Denver 7
Hải Dương 7
Jakarta 7
Olomouc 7
The Dalles 7
Crotone 6
Messina 6
Naples 6
San Mateo 6
Stockholm 6
Tashkent 6
Warsaw 6
Cagliari 5
Columbus 5
Council Bluffs 5
Dongyang 5
Florence 5
Guayaquil 5
Lamezia Terme 5
Montreal 5
Napoli 5
Rio de Janeiro 5
San Jose 5
Shenzhen 5
Toronto 5
Weihai 5
Assago 4
Brasília 4
Casoria 4
Catania 4
Genoa 4
Heidesheim 4
Lahore 4
Mexico City 4
Montevideo 4
Phoenix 4
Porto Alegre 4
Quảng Ngãi 4
Redwood City 4
Santander 4
Siena 4
Zhengzhou 4
Alassio 3
Amman 3
Ballabio 3
Bari 3
Belo Horizonte 3
Bogotá 3
Can Tho 3
Cosenza 3
Dhaka 3
Totale 3.095
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Nome #
A Candidate multi-targeting approach to block the CD98hc oncoprotein 94
A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine. 85
GBPM: applicazione al docking molecolare 83
Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome 78
Application of standard and enhanced sampling approaches on non-canonical structures of DNA and RNA 71
Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses 70
Abstract B122: The CD98hc oncoprotein as a target of new anticancer therapy 69
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity 68
Back Cover: Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement (ChemMedChem 16/2016) 67
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application 67
Identification and Characterization of New DNA G-Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches 64
The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile 63
Molecular recognition of a carboxy pyridostatin towards G-quadruplex structures: why does it prefer RNA? 62
A Comparative Docking Strategy to Identify Polyphenolic Derivatives as Promising Antineoplastic Binders of G-quadruplex DNA c-myc and bcl-2 Sequences 61
DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation 61
In Silico and In Vitro Study of Antioxidant Potential of Urolithins 60
Chemoinformatic database building and in silico hit-identification of potential multi-targeting bioactive compounds extracted from mushroom species 60
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold 59
3-Acetyl-25-diaryl-23-dihydro-134-oxadiazoles: a new scaffold for the selective inhibition of monoamine oxidase B 58
SI113, a Specific Inhibitor of the Sgk1 Kinase Activity that Counteracts Cancer Cell Proliferation 58
Active Components of Essential Oils as Anti-Obesity Potential Drugs Investigated by in Silico Techniques 57
(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies. 57
Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures 56
Molecular recognition studies of dasabuvir, tegobuvir, and setrobuvir against natural Hepatitis C Virus NS5B polymerase variants. 56
C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships. 55
Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement 55
Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach 54
ABCC Transporters Mediate the Vacuolar Accumulation of Crocins in Saffron Stigmas 54
Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization 54
Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin 53
Discovery of pyridoquinoxaline-based new P-gp inhibitors as coadjutant against Multi Drug Resistance in cancer 53
In Silico Identification of Piperidinyl-amine Derivatives as Novel Dual Binders of Oncogene c-myc/c-Kit G-quadruplexes 53
Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties 52
A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors 52
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists 51
Comparison of Computational Methods in Docking Experiments of G-Quadruplex Binders 51
Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents 51
In silico identification and biological evaluation of antioxidant food components endowed with IX and XII hCA inhibition 51
Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition 51
Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds 50
Identification and Structural Characterization of Novel Genetic Elements in HIV-1 - V3 Loop Regulating Co-Receptor Usage 50
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques 50
Identification of New Natural DNA G-Quadruplex Binders Selected by a Structure-Based Virtual Screening Approach 50
Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics 49
Identification of Compounds Targeting HuD. Another Brick in the Wall of Neurodegenerative Disease Treatment 49
Natural products extracted from fungal species as new potential anti-cancer drugs: A structure-based drug repurposing approach targeting HDAC7 48
Multi-targeting bioactive compounds extracted from essential oils as kinase inhibitors 48
From Homology Modeling to the Hit Identification and Drug Repurposing: A Structure-Based Approach in the Discovery of Novel Potential Anti-Obesity Compounds 47
TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line. 47
Computer-based techniques for lead identification and optimization i: Basics 46
Neurodegeneration: can metabolites from Eremurus persicus help? 45
GRID-based three-dimensional pharmacophores II: PharmBench, a benchmark data set for evaluating pharmacophore elucidation methods 45
Targeting multiple G-quadruplex–forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives 44
The non-coding RNA landscape of plasma cell dyscrasias 44
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands 43
Hepatitis C Virus Genetic Variability and the Presence of NS5B Resistance-Associated Mutations as Natural Polymorphisms in Selected Genotypes Could Affect the Response to NS5B Inhibitors 43
Identification of new G-quadruplex binders by combined virtual screening approaches. 43
Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders 42
Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids. 41
Extended Naphthalene Diimides with Donor/Acceptor Hydrogen-Bonding Properties Targeting G-Quadruplex Nucleic Acids 40
Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach 39
Identification of SET/EED dual binders as innovative PRC2 inhibitors 39
Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage 39
Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase 39
Metodi computazionali e nutraceutica 39
Uncovering Novel Capsaicin Inhibitory Activity towards Human Carbonic Anhydrase Isoforms IX and XII by Combining In Silico and In Vitro Studies 38
Conformation and stability of intramolecular telomeric g-quadruplexes: sequence effects in the loops 38
Exploring new chemical functionalities to improve aromatase inhibition of steroids 38
Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains. 38
An overview on olfaction in the biological, analytical, computational, and machine learning fields 38
Molecular and Structural Aspects of Clinically Relevant Mutations of SARS-CoV-2 RNA-Dependent RNA Polymerase in Remdesivir-Treated Patients 37
Computational study on DNA G-quadruplex binding compounds 37
Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control 37
Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile 36
Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery? 36
Computer-based techniques for lead identification and optimization I: Basics 35
Computational approaches for discovery and optimization of G-quadruplex binders 35
Short- and Long-Term Regulation of HuD: A Molecular Switch Mediated by Folic Acid? 34
Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations 34
Kaempferol as Selective Human MAO-A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies 34
Docking comparativo nello sviluppo di ligandi per il DNA G-quadruplex 34
Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir containing regimens 34
Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance 34
Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products 33
Molecular Recognition Of Dna G-Quadruplex Ligands By Different Docking Methods 33
Molecular interaction fields in drug discovery: recent advances and future perspectives 33
Natural Agents as Novel Potential Source of Proteasome Inhibitors with Anti-Tumor Activity: Focus on Multiple Myeloma 32
Mediterranean Diet: The Beneficial Effects of Lycopene in Non-Alcoholic Fatty Liver Disease 32
Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral treated HIV-1 infected patients, all naïve to integrase inhibitors 32
New raltegravir resistance pathways induce broad cross-resistance to all currently used integrase inhibitors 32
Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity 32
Structure-based pharmacophore modeling of DNA G-Quadruplex ligand-complexes. 32
Structural Modeling of New Polymorphism Clusters of HCV Polymerase Isolated from Direct-Acting Antiviral Naïve Patients: Focus on Dasabuvir and Setrobuvir Binding Affinity 31
Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7β substituted steroids 30
Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa-Part 2 30
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity 30
Simple choline esters as potential anti-Alzheimer agents 30
Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage 30
Molecular docking, synthesis and biological evaluation of indomethacin analogs as novel cyclooxygenase inhibitors. 30
The polymorphisms of DNA g-quadruplex investigated by docking experiments with telomestatin enantiomers 30
Totale 4.712
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Categoria #
all - tutte 54.642
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.642
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202187 0 0 0 0 0 17 24 4 15 13 9 5
2021/2022294 2 2 7 59 13 4 18 68 22 37 58 4
2022/2023935 210 42 47 57 93 77 11 67 154 58 95 24
2023/2024546 85 68 48 36 42 136 16 46 6 20 26 17
2024/20251.483 181 98 51 37 115 171 78 46 193 64 170 279
2025/20261.916 192 357 526 443 314 84 0 0 0 0 0 0
Totale 5.443